HDAd6/35++ - A new helper-dependent adenovirus vector platform for in vivo transduction of hematopoietic stem cells

HDAd6/35++ - A new helper-dependent adenovirus vector platform for in vivo transduction of hematopoietic stem cells

In previous studies, we achieved safe and efficient in vivo hematopoietic stem cell (HSC) transduction in mobilized mice and macaques with intravenously injected helper-dependent adenovirus HDAd5/35++ vectors. These vectors are derivatives of serotype Ad5-containing CD46-affinity enhanced Ad35 fiber...

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Bibliographic Details
Main Authors: Hongjie Wang, Aphrodite Georgakopoulou, Wenli Zhang, Jiho Kim, Sucheol Gil, Anja Ehrhardt, André Lieber
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
in vivo HSC gene therapy
adenovirus serotype 6
serum prevalence
helper-dependent adenovirus vector
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300044X

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http://www.sciencedirect.com/science/article/pii/S232905012300044X

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