Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis

Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis

Abstract Background The dynamic interaction between cancer cells and tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is an active barrier to the effector arm of the antitumour immune response. Cancer-secreted exosomes are emerging mediators of this cancer-stromal cr...

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Bibliographic Details
Main Authors: Xiao-Jing Chen, Chu-Hong Guo, Zi-Ci Wang, Yang Yang, Yu-Hua Pan, Jie-Ying Liang, Mei-Ge Sun, Liang-Sheng Fan, Li Liang, Wei Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Cervical cancer
Hypoxia
Immune evasion
Exosome
CD47-SIRPα axis
Online Access:https://doi.org/10.1186/s12964-023-01450-4

Internet

https://doi.org/10.1186/s12964-023-01450-4

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