Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

Impaired spermatogenesis and male infertility are common manifestations associated with mitochondrial diseases, yet the underlying mechanisms linking these conditions remain elusive. In this study, we demonstrate that mice deficient for the mitochondrial intra-membrane rhomboid protease PARL, a rece...

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Bibliographic Details
Main Authors: Enrico Radaelli, Charles-Antoine Assenmacher, Jillian Verrelle, Esha Banerjee, Florence Manero, Salim Khiati, Anais Girona, Guillermo Lopez-Lluch, Placido Navas, Marco Spinazzi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
PARL
ferroptosis
GPX4
coenzyme Q
spermatogenesis
mitochondria
Online Access:https://elifesciences.org/articles/84710

Internet

https://elifesciences.org/articles/84710

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