Functional and Immune Modulatory Characteristics of Bone Marrow Mesenchymal Stromal Cells in Patients With Aplastic Anemia: A Systematic Review

Functional and Immune Modulatory Characteristics of Bone Marrow Mesenchymal Stromal Cells in Patients With Aplastic Anemia: A Systematic Review

BackgroundIn most patients with aplastic anemia (AA), the diagnosis is limited to a description of the symptoms. Lack of understanding of the underlying pathophysiological mechanisms causing bone marrow failure (BMF), hampers tailored treatment. In these patients, auto-immune cell-mediated destructi...

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Bibliographic Details
Main Authors: Khaled Atmar, Adam J. Tulling, Arjan C. Lankester, Marije Bartels, Frans J. Smiers, Mirjam van der Burg, Alexander B. Mohseny
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
aplastic anaemia (AA)
bone marrow failure (BMF)
mesenchymal stem (stromal) cell
immunomodulation
hematopoietic regulation
lineage specific differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859668/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.859668/full

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