PXR Suppresses PPARα-Dependent <i>HMGCS2</i> Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

PXR Suppresses PPARα-Dependent <i>HMGCS2</i> Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs. Our group recently reported a possible drug–drug inter...

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Bibliographic Details
Main Authors: Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
PXR
PPARα
PGC1α
nuclear receptor
coactivator
gene transcription
Online Access:https://www.mdpi.com/2073-4409/10/12/3550

Internet

https://www.mdpi.com/2073-4409/10/12/3550

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