An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential <em>GSK3β</em>/<em>β-Catenin</em>/<em>STAT3</em>/<em>CD44</em> Suppressor with Anti-Glioblastoma Properties

An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential <em>GSK3β</em>/<em>β-Catenin</em>/<em>STAT3</em>/<em>CD44</em> Suppressor with Anti-Glioblastoma Properties

Despite management efforts with standard surgery, radiation, and chemotherapy, glioblastoma multiform (GBM) remains resistant to treatment, which leads to tumor recurrence due to glioma stem cells (GSCs) and therapy resistance. In this study, we used random computer-based prediction and target ident...

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Bibliographic Details
Main Authors: Ntlotlang Mokgautsi, Ya-Ting Wen, Bashir Lawal, Harshita Khedkar, Maryam Rachmawati Sumitra, Alexander T. H. Wu, Hsu-Shan Huang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme (GBM)
tumor microenvironment (TME)
glioma stem cell (GSC)
stemness
drug resistance
in silico molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/5/2464

Internet

https://www.mdpi.com/1422-0067/22/5/2464

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