Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

BACKGROUND:DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly elevated homocysteine: MTHFR 677C>T independe...

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প্রধান লেখক: Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemans, Chunyu Liu, Allan F McRae, Michael M Mendelson, Martina Müller-Nurasyid, Annette Peters, P Eline Slagboom, John M Starr, David-Alexandre Trégouët, André G Uitterlinden, Marleen M J van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S Wells, Chen Yao, Ian J Deary, France Gagnon, Bastiaan T Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G Heil, Joyce B J van Meurs, CHARGE Consortium Epigenetics group and BIOS Consortium
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: Public Library of Science (PLoS) 2017-01-01
মালা:PLoS ONE
অনলাইন ব্যবহার করুন:http://europepmc.org/articles/PMC5662081?pdf=render

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http://europepmc.org/articles/PMC5662081?pdf=render

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