Universal CAR T cells targeted to HER2 with a biotin-trastuzumab soluble linker penetrate spheroids and large tumor xenografts that are inherently resistant to trastuzumab mediated ADCC

Universal CAR T cells targeted to HER2 with a biotin-trastuzumab soluble linker penetrate spheroids and large tumor xenografts that are inherently resistant to trastuzumab mediated ADCC

CAR T cell therapies face challenges in combating solid tumors due to their single-target approach, which becomes ineffective if the targeted antigen is absent or lost. Universal CAR T cells (UniCAR Ts) provide a promising solution by utilizing molecular tags (linkers), such as biotin conjugated to...

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Bibliographic Details
Main Authors: Lőrinc Nagy, Marianna Mezősi-Csaplár, István Rebenku, György Vereb, Árpád Szöőr
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
breast cancer
HER2
trastuzumab, universal chimeric antigen receptor
immunotherapy
cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1365172/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1365172/full

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