Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds

Abstract Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neurona...

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Bibliographic Details
Main Authors: Marta Perez-Rando, Simon Dujardin, Rachel E. Bennett, Caitlin Commins, Tara Nibhanupudy, Bradley T. Hyman
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neurofibrillary tangles
Tau seeding
RNA expression
Online Access:http://link.springer.com/article/10.1186/s40478-020-01049-7

Internet

http://link.springer.com/article/10.1186/s40478-020-01049-7

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