Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial

Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial

Abstract Background Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammatio...

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Bibliographic Details
Main Authors: Andrew W. Kirkpatrick, Federico Coccolini, Luca Ansaloni, Derek J. Roberts, Matti Tolonen, Jessica L. McKee, Ari Leppaniemi, Peter Faris, Christopher J. Doig, Fausto Catena, Timothy Fabian, Craig N. Jenne, Osvaldo Chiara, Paul Kubes, Braden Manns, Yoram Kluger, Gustavo P. Fraga, Bruno M. Pereira, Jose J. Diaz, Michael Sugrue, Ernest E. Moore, Jianan Ren, Chad G. Ball, Raul Coimbra, Zsolt J. Balogh, Fikri M. Abu-Zidan, Elijah Dixon, Walter Biffl, Anthony MacLean, Ian Ball, John Drover, Paul B. McBeth, Juan G. Posadas-Calleja, Neil G. Parry, Salomone Di Saverio, Carlos A. Ordonez, Jimmy Xiao, Massimo Sartelli, for The Closed Or Open after Laparotomy (COOL) after Source Control for Severe Complicated Intra-Abdominal Sepsis Investigators
Format: Article
Language:English
Published: BMC 2018-06-01
Series:World Journal of Emergency Surgery
Subjects:
Intra-peritoneal sepsis
Septic shock
Peritonitis
Open-abdomen
Multiple organ dysfunction
Laparotomy
Online Access:http://link.springer.com/article/10.1186/s13017-018-0183-4

Internet

http://link.springer.com/article/10.1186/s13017-018-0183-4

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