Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation an...

Full description

Bibliographic Details
Main Authors: Fatma Saaoud, Junfeng Wang, Stephen Iwanowycz, Yuzhen Wang, Diego Altomare, Ying Shao, Jianguo Liu, Perry J. Blackshear, Susan M. Lessner, E. Angela Murphy, Hong Wang, Xiaofeng Yang, Daping Fan
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Tristetraprolin
Lipid metabolism
Lipoprotein
Inflammation
Atherosclerosis
Hepatic steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308144

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720308144

Similar Items