Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1

Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1

An exchange protein directly activated by cAMP 1 (EPAC1) is an intracellular sensor for cAMP that is involved in a wide variety of cellular and physiological processes in health and disease. However, reagents are lacking to study its association with intracellular cAMP nanodomains. Here, we use non-...

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Bibliographic Details
Main Authors: Hanna K. Buist, Urszula Luchowska-Stańska, Boy van Basten, Jessica Valli, Brian O. Smith, George S. Baillie, Colin Rickman, Bryon Ricketts, Alex Davidson, Ryan Hannam, Joanne Sunderland, Stephen J. Yarwood
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
EPAC1
cyclic AMP
affimer
microscopy
protein interactions
phage display
Online Access:https://www.mdpi.com/2073-4409/10/9/2307

Internet

https://www.mdpi.com/2073-4409/10/9/2307

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