Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>)
Malformations in the development of the neural tube have been described to be associated with different aetiologies, such as genetic factors, toxic plants, chemical products, viral agents, or hyperthermia. A twenty-four-year-old female Eurasian brown bear (<i>Ursus arctos arctos</i>), pe...
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MDPI AG
2022-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/18/2345 |
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| author | Ana Balseiro Laura Polledo José Tuñón Juan Francisco García Marín |
| author_facet | Ana Balseiro Laura Polledo José Tuñón Juan Francisco García Marín |
| author_sort | Ana Balseiro |
| collection | DOAJ |
| description | Malformations in the development of the neural tube have been described to be associated with different aetiologies, such as genetic factors, toxic plants, chemical products, viral agents, or hyperthermia. A twenty-four-year-old female Eurasian brown bear (<i>Ursus arctos arctos</i>), permanently in captivity and kept under food and management control, gave birth to a stillborn cub at the end of gestation. Several malformations resulting from the anomalous development of the neural tube, not previously reported in bears, were observed, such as anencephaly, hypoplasia, micromyelia, severe myelodysplasia, syringomyelia, and spina bifida. Multiple canal defects (e.g., absence) were also observed in the spinal cord. In some regions, the intradural nerve roots surrounded the spinal cord in a diffuse and continuous way. The aetiology remains unidentified, although the advanced age of the mother and/or folic acid deficit might have been the possible causes of this disorder. Supplements of folate given to the mother before and during early pregnancy may have reduced the incidence of neural tube defects. That supplementation should be considered when the reproduction of bears is to occur in captivity, in order to prevent the loss of future generations of this endangered species. |
| first_indexed | 2024-03-10T00:56:55Z |
| format | Article |
| id | doaj.art-a89dd1a3482c46f290495cf7d9128fed |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T00:56:55Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-a89dd1a3482c46f290495cf7d9128fed2023-11-23T14:41:23ZengMDPI AGAnimals2076-26152022-09-011218234510.3390/ani12182345Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>)Ana Balseiro0Laura Polledo1José Tuñón2Juan Francisco García Marín3Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, SpainDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, SpainFundación Oso Asturias, 33114 Proaza, SpainDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, SpainMalformations in the development of the neural tube have been described to be associated with different aetiologies, such as genetic factors, toxic plants, chemical products, viral agents, or hyperthermia. A twenty-four-year-old female Eurasian brown bear (<i>Ursus arctos arctos</i>), permanently in captivity and kept under food and management control, gave birth to a stillborn cub at the end of gestation. Several malformations resulting from the anomalous development of the neural tube, not previously reported in bears, were observed, such as anencephaly, hypoplasia, micromyelia, severe myelodysplasia, syringomyelia, and spina bifida. Multiple canal defects (e.g., absence) were also observed in the spinal cord. In some regions, the intradural nerve roots surrounded the spinal cord in a diffuse and continuous way. The aetiology remains unidentified, although the advanced age of the mother and/or folic acid deficit might have been the possible causes of this disorder. Supplements of folate given to the mother before and during early pregnancy may have reduced the incidence of neural tube defects. That supplementation should be considered when the reproduction of bears is to occur in captivity, in order to prevent the loss of future generations of this endangered species.https://www.mdpi.com/2076-2615/12/18/2345brown bear<i>Ursus arctos arctos</i>congenital nervous system malformationanencephalyspina bifidamyelodysplasia |
| spellingShingle | Ana Balseiro Laura Polledo José Tuñón Juan Francisco García Marín Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) Animals brown bear <i>Ursus arctos arctos</i> congenital nervous system malformation anencephaly spina bifida myelodysplasia |
| title | Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) |
| title_full | Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) |
| title_fullStr | Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) |
| title_full_unstemmed | Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) |
| title_short | Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (<i>Ursus arctos arctos</i>) |
| title_sort | anencephaly and severe myelodysplasia in a stillborn brown bear i ursus arctos arctos i |
| topic | brown bear <i>Ursus arctos arctos</i> congenital nervous system malformation anencephaly spina bifida myelodysplasia |
| url | https://www.mdpi.com/2076-2615/12/18/2345 |
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