Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies

Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies

Herpes simplex virus-1 (HSV-1) is highly contagious, and there is a need for a therapeutic means to eradicate it. We have identified an siRNA (siHSV) that knocks down gene expression of the infected cell protein 0 (ICP0), which is important in the regulation of HSV infection. The selected siHSV was...

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Bibliographic Details
Main Authors: Doaa Jbara-Agbaria, Saskia Blondzik, Anke Burger-Kentischer, Majd Agbaria, Mirjam M. Nordling-David, Anna Giterman, Gil Aizik, Steffen Rupp, Gershon Golomb
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
nanomedicine
liposomes
gene delivery
HSV-1
3D epidermis model
Online Access:https://www.mdpi.com/1999-4923/14/3/633

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https://www.mdpi.com/1999-4923/14/3/633

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