Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake

Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake

Background: Andrographolide (ADR), the main active component of Andrographis paniculata, displays anticancer activity in various cancer cell lines, among which leukemia cell lines exhibit the highest sensitivity to ADR. In particular, ADR was also reported to have reduced drug resistance in multidru...

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Bibliographic Details
Main Authors: Xiao Chen, Jianbin Zhang, Lixia Yuan, Yifei Lay, Yin Kwan Wong, Teck Kwang Lim, Chye Sun Ong, Qingsong Lin, Jigang Wang, Zichun Hua
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
andrographolide
fatty acid synthesis
FLT3 signaling
intracellular iron pool
MV4-11
protein synthesis
quantitative proteomics
Online Access:https://www.mdpi.com/1420-3049/22/9/1444

Internet

https://www.mdpi.com/1420-3049/22/9/1444

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