Evaluation of galantamine and deconstructed analogs as α7 nAChR and AChE ligands

Galantamine (1), one of only five agents currently approved for the treatment of Alzheimer’s disease, is thought to act primarily as an inhibitor of acetylcholinesterase (AChE) and possibly as a positive allosteric modulator (PAM) of neuronal α7 nicotinic acetylcholine (nACh) receptors. Here, the st...

Full description

Bibliographic Details
Main Authors: Malaika D. Argade, Laura DeCristofano, Nirajan Bhattarai, Marvin K. Schulte, Malgorzata Dukat
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622000054