Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necessitating the development of novel therapeutics, especially those able to target che...

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Bibliographic Details
Main Authors: Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono, Shruthi Sanjitha Sampath, Tina M. O’Grady, Melody Baddoo, Liang Haoyang, Xiaojiang Xu, Erik K. Flemington, Sean B. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00504-z

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https://doi.org/10.1038/s41389-023-00504-z

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