Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice

Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice

ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and central nervous system. Unfortunately, the KATP channels exis...

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Bibliographic Details
Main Authors: Cole Fisher, Kayla Johnson, Travis Okerman, Taylor Jurgenson, Austin Nickell, Erin Salo, Madelyn Moore, Alexis Doucette, James Bjork, Amanda H. Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
opioid
tolerance
withdrawal
KATP channels
SUR1
analgesia
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01122/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01122/full

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