Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions

Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions

Abstract NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological processes. NEDD8-activating enzyme (NAE) as the only activation enzyme in the NEDDylation modification has become an attractive target to develop...

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Bibliographic Details
Main Authors: Dong-Jun Fu, Ting Wang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Hematology & Oncology
Subjects:
NEDDylation
NAE
Cancer therapy
Challenges
Development directions
Online Access:https://doi.org/10.1186/s13045-023-01485-7

Internet

https://doi.org/10.1186/s13045-023-01485-7

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