DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features

DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features

The decreased antioxidant capacity in the retinal pigment epithelium (RPE) is the hallmark of retinal degenerative diseases including age-related macular degeneration (AMD). Nevertheless, the exact regulatory mechanisms underlying the pathogenesis of retinal degenerations remain largely unknown. Her...

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Bibliographic Details
Main Authors: Xiaoyin Ma, Huaicheng Chen, Shuhui Jian, Junhao He, Youjia Liu, Shuxian Han, Lifu Chang, Pingping Li, Ying-ao Chen, Xiaoyan Liu, Xiaojuan Hu, Yu Chen, Ling Hou
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Oxidative stress
MITF
Pigment cell
AMD
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000769

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http://www.sciencedirect.com/science/article/pii/S2213231723000769

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