Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial

Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial

IntroductionFunctional cure has been proposed as an alternative to lifelong antiretroviral therapy and therapeutic vaccines represent one of the most promising approaches.Materials and MethodsWe conducted a double-blind randomized placebo-controlled clinical trial to evaluate the safety, immunogenic...

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Main Authors: Lorna Leal, Elvira Couto, Sonsoles Sánchez-Palomino, Núria Climent, Irene Fernández, Laia Miralles, Yolanda Romero, Tania González, Maria José Maleno, Blanca Paño, Judit Pich, Carlos Nicolau, José Maria Gatell, Montserrat Plana, Felipe García, the DCV3-RISVAC04 Study Group, Irene Fernández, Carmen Hurtado, Núria Climent, Tania González, Maria José Maleno, Laura Burunat, Joan Albert Arnaiz, Blanca Paño, Rafael Salvador, Elisabet Farré, Sonsoles Sánchez-Palomino, José Maria Gatell, Felipe García, Berta Torres, Constanza Lucero, Montserrat Laguno, María Martínez-Rebollar, Ana González-Cordón, John Rojas, Alexy Inciarte, Lorena de la Mora, Josep Mallolas, Esteban Martínez, José Luis Blanco, Unai Perpiñá, Josep Canals, Raquel Martín, Florencia Echeverry, Cristina Xufré, Cristina Rovira, Marta Sala, Amparo Tricas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
therapeutic vaccine
dendritic cell
interferon alpha
combined strategy
ATI
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.767370/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.767370/full

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