Bruton’s tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome

Bruton’s tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome

Hemolytic-uremic syndrome (HUS) can occur as a complication of an infection with Shiga-toxin (Stx)-producing Escherichia coli. Patients typically present with acute kidney injury, microangiopathic hemolytic anemia and thrombocytopenia. There is evidence that Stx-induced renal damage propagates a pro...

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Bibliographic Details
Main Authors: Sarah Kröller, Bianka Wissuwa, Sophie Dennhardt, Nadine Krieg, Christoph Thiemermann, Christoph Daniel, Kerstin Amann, Florian Gunzer, Sina M. Coldewey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
hemolytic-uremic syndrome
acute kidney injury
inflammation
animal model
Bruton’s tyrosine kinase
ibrutinib
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1105181/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1105181/full

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