Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans

Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans

Using combined genetic mapping, Illumina sequencing, bioinformatics analyses, and experimental validation, we identified 60 essential genes from 104 lethal mutations in two genomic regions of Caenorhabditis elegans totaling ∼14 Mb on chromosome III(mid) and chromosome V(left). Five of the 60 genes h...

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Bibliographic Details
Main Authors: Zhaozhao Qin, Robert Johnsen, Shicheng Yu, Jeffrey Shih-Chieh Chu, David L. Baillie, Nansheng Chen
Format: Article
Language:English
Published: Oxford University Press 2018-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
essential gene
lethal
genetic balancer
whole genome sequencing (WGS)
functional characterization
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300338

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http://g3journal.org/lookup/doi/10.1534/g3.117.300338

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