The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinfl...

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Bibliographic Details
Main Authors: Lorenzo Cuollo, Fabrizio Antonangeli, Angela Santoni, Alessandra Soriani
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biology
Subjects:
senescence
SASP
inflammation
cancer therapy
age-related disease
senolytic
Online Access:https://www.mdpi.com/2079-7737/9/12/485

Internet

https://www.mdpi.com/2079-7737/9/12/485

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