Can non-lytic CD8+ T cells drive HIV-1 escape?

Can non-lytic CD8+ T cells drive HIV-1 escape?

The CD8+ T cell effector mechanisms that mediate control of HIV-1 and SIV infections remain poorly understood. Recent work suggests that the mechanism may be primarily non-lytic. This is in apparent conflict with the observation that SIV and HIV-1 variants that escape CD8+ T cell surveillance are fr...

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Bibliographic Details
Main Authors: Nafisa-Katrin Seich Al Basatena, Konstantinos Chatzimichalis, Frederik Graw, Simon D W Frost, Roland R Regoes, Becca Asquith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3828169?pdf=render

Internet

http://europepmc.org/articles/PMC3828169?pdf=render

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