Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment

Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment

Abstract Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus. However, underlying molecular programs that guide iNKT subset differentiation remain unclear. Here, we profiled the transcriptomes of...

Full description

Bibliographic Details
Main Authors: Jie Wang, Indra Adrianto, Kalpana Subedi, Tingting Liu, Xiaojun Wu, Qijun Yi, Ian Loveless, Congcong Yin, Indrani Datta, Derek B. Sant’Angelo, Mitchell Kronenberg, Li Zhou, Qing-Sheng Mi
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00547-x

Internet

https://doi.org/10.1038/s41421-023-00547-x

Similar Items