PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells

PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells

Thrombin stimulates platelets via a dual receptor system of protease-activated receptors (PARs): PAR1 and PAR4. PAR1 activation induces a rapid and transient signal associated with the initiation of platelet aggregation, whereas PAR4 activation results in a prolonged signal, required for later phase...

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Bibliographic Details
Main Authors: Yunkyung Heo, Hyejin Jeon, Wan Namkung
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
MEG-01
platelet
thrombin
PAR1
PAR4
morphological change
Online Access:https://www.mdpi.com/1422-0067/23/2/776

Internet

https://www.mdpi.com/1422-0067/23/2/776

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