SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 infection leads to lung injury remains elusive. The open reading frame 8 (ORF8) protein of SARS-CoV-2 (ORF8SARS-CoV-2) is a unique a...

Full description

Bibliographic Details
Main Authors: Hua Geng, Saravanan Subramanian, Longtao Wu, Heng-Fu Bu, Xiao Wang, Chao Du, Isabelle G. De Plaen, Xiao-Di Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2 accessory protein
ORF8
lung epithelial cells
interferon signaling
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679482/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.679482/full

Similar Items