Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation

Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation

Abstract Chronic stress is the primary environmental risk factor for major depressive disorder (MDD), and there is compelling evidence that neuroinflammation is the major pathomechanism linking chronic stress to MDD. Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a negative regulat...

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Bibliographic Details
Main Authors: Mengjun Geng, Qiujing Shao, Jiacheng Fu, Jingyang Gu, Laipeng Feng, Liqin Zhao, Cong Liu, Junlin Mu, Xiaoli Zhang, Mingjun Zhao, Xinsheng Guo, Cai Song, Yan Li, Huiying Wang, Changhong Wang
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02846-7

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https://doi.org/10.1038/s41398-024-02846-7

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