Novel [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity

Novel [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity

This study of the interaction system of binucleophilic 3-substituted 4-amino-4<i>H</i>-1,2,4-triazole-5-thiols and 3-phenyl-2-propynal made it possible to develop a new approach to synthesis of such isomeric classes as 7-benzylidene-[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadia...

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Bibliographic Details
Main Authors: Andrey V. Khramchikhin, Mariya A. Skryl’nikova, Iana L. Esaulkova, Ekaterina O. Sinegubova, Vladimir V. Zarubaev, Maxim A. Gureev, Aleksandra M. Puzyk, Vladimir A. Ostrovskii
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
drug design
annelated heterocycles
influenza virus
anti-viral activity
[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazines
[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazepines
Online Access:https://www.mdpi.com/1420-3049/27/22/7940

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https://www.mdpi.com/1420-3049/27/22/7940

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