Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.

Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.

Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insulin resistance and inflammation in mice....

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Bibliographic Details
Main Authors: Andoni Lancha, Amaia Rodríguez, Victoria Catalán, Sara Becerril, Neira Sáinz, Beatriz Ramírez, María A Burrell, Javier Salvador, Gema Frühbeck, Javier Gómez-Ambrosi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4037189?pdf=render

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http://europepmc.org/articles/PMC4037189?pdf=render

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