Tumor-Infiltrating T Cells in EBV-Associated Gastric Carcinomas Exhibit High Levels of Multiple Markers of Activation, Effector Gene Expression, and Exhaustion

Tumor-Infiltrating T Cells in EBV-Associated Gastric Carcinomas Exhibit High Levels of Multiple Markers of Activation, Effector Gene Expression, and Exhaustion

Epstein–Barr virus (EBV) is a gamma-herpesvirus associated with 10% of all gastric cancers (GCs) and 1.5% of all human cancers. EBV-associated GCs (EBVaGCs) are pathologically and clinically distinct entities from EBV-negative GCs (EBVnGCs), with EBVaGCs exhibiting differential molecular pathology,...

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Bibliographic Details
Main Authors: Mikhail Salnikov, Martin A. Prusinkiewicz, Sherman Lin, Farhad Ghasemi, Matthew J. Cecchini, Joe S. Mymryk
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
Epstein–Barr virus
gastric cancer
TCGA
gene expression
immune landscape
lymphocyte infiltration
Online Access:https://www.mdpi.com/1999-4915/15/1/176

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https://www.mdpi.com/1999-4915/15/1/176

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