Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands

Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands

In silico approaches were employed to examine the characteristics of interactions between human mitochondrial thioredoxin 2 (HsTrx2) and its 38 previously identified mitochondrial protein ligands. All interactions appeared driven mainly by electrostatic forces. The statistically significant residues...

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Bibliographic Details
Main Authors: Charalampos Ntallis, Haralampos Tzoupis, Theodore Tselios, Christos T. Chasapis, Alexios Vlamis-Gardikas
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antioxidants
Subjects:
thioredoxin
mitochondria
hot spots
contact area
interface
molecular recognition
Online Access:https://www.mdpi.com/2076-3921/13/1/15

Internet

https://www.mdpi.com/2076-3921/13/1/15

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