Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels

Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels

Abstract Spontaneous action potentials precede phasic contractile activity in human collecting lymphatic vessels. In this study, we investigated the expression of hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in human collecting lymphatics and by pharmacological inhibition ex vi...

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Bibliographic Details
Main Authors: Jens Majgaard, Frederik G. Skov, Sukhan Kim, Vibeke Elisabeth Hjortdal, Donna M. B. Boedtkjer
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Physiological Reports
Subjects:
HCN2
histamine
ivabradine
lymph vessel
lymphatic smooth muscle
Online Access:https://doi.org/10.14814/phy2.15401

Internet

https://doi.org/10.14814/phy2.15401

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