Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity

Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity

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G-quadruplex is a non-canonical secondary structure identified in the telomeric region and the promoter of many oncogenes. Anthraquinone derivatives, a well-known inducer of telomere disruption in malignant cells and activate the apoptotic pathway. We used biophysical and biochemical studies to conf...

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Bibliographic Details
Main Authors: Arpita Dey, Kumud Pandav, Mala Nath, Ritu Barthwal, Ramasare Prasad
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and applications
G quadruplex
sensogram
anthraquinone derivative
spectroscopic study
groove binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122003006

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http://www.sciencedirect.com/science/article/pii/S2162253122003006

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