Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells

Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested whether chimeric engulfment receptor (CER) T cel...

Full description

Bibliographic Details
Main Authors: Daniel Corey, Francoise Haeseleer, Joe Hou, Lawrence Corey
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
SIV
HIV
chimeric engulfment receptor (CER)
TIM-4
phosphatidylserine
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001632

Internet

http://www.sciencedirect.com/science/article/pii/S2329050122001632

Similar Items