Identification and Characterization of Novel Small-Molecule SMOX Inhibitors

The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine oxidase that is upregulated during excitotoxi...

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Bibliographic Details
Main Authors: Amelia B. Furbish, Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. Casero, Patrick M. Woster
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Medical Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3271/10/3/47