Ochratoxin A triggers endoplasmic reticulum stress through PERK/NRF2 signaling and DNA damage during early embryonic developmental competence in pigs

Ochratoxin A triggers endoplasmic reticulum stress through PERK/NRF2 signaling and DNA damage during early embryonic developmental competence in pigs

Ochratoxin A (OTA), a mycotoxin found in foods, has a deleterious effect on female reproduction owing to its endocrine-disrupting activity mediated through endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) production. However, the mechanisms of OTA-induced ER stress in pig embryos...

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Bibliographic Details
Main Authors: Seong-Min Woo, Seul-Gi Yang, Ye-Won Kim, Deog-Bon Koo, Hyo-Jin Park
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ochratoxin A
Oxidative stress
ER-stress
PERK/NRF2 signaling
Porcine embryos
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323012617

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http://www.sciencedirect.com/science/article/pii/S0147651323012617

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