Simultaneous Quantification of Propylthiouracil and Its <i>N</i>-β-<span style="font-variant: small-caps">d</span> Glucuronide by HPLC-MS/MS: Application to a Metabolic Study

Simultaneous Quantification of Propylthiouracil and Its <i>N</i>-β-<span style="font-variant: small-caps">d</span> Glucuronide by HPLC-MS/MS: Application to a Metabolic Study

Propylthiouracil (PTU) is commonly prescribed for the management of hyperthyroidism and thyrotoxicosis. Although the exact mechanism of action is not fully understood, PTU is associated with hepatoxicity in pediatric population. Glucuronidation mediated by uridine 5′-diphospho-glucuronosyltransferas...

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Bibliographic Details
Main Authors: Min Li, Qingfeng He, Li Yao, Xiaofeng Wang, Zhijia Tang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
propylthiouracil
propylthiouracil glucuronide
in vitro
human liver microsomes
UGT1A9
HPLC-MS/MS
Online Access:https://www.mdpi.com/1424-8247/14/11/1194

Internet

https://www.mdpi.com/1424-8247/14/11/1194

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