ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors

ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors

This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5′-diphosphate (ADP, 100 µmol·L<sup>−1</sup>) Platelet-rich plasma (PRP) was prepared from the bl...

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Bibliographic Details
Main Authors: Ronald Anderson, Annette J. Theron, Helen C. Steel, Jan G. Nel, Gregory R. Tintinger
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
adenosine 5′-diphosphate
cytosolic calcium
phospholipase C
phosphatidylinositol 3-kinase
platelets
P2Y1/P2Y12 receptors
Online Access:https://www.mdpi.com/1424-8247/13/12/420

Internet

https://www.mdpi.com/1424-8247/13/12/420

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