Altered Expression of ZO-1 and ZO-2 in Sertoli Cells and Loss of Blood-Testis Barrier Integrity in Testicular Carcinoma In Situ

Altered Expression of ZO-1 and ZO-2 in Sertoli Cells and Loss of Blood-Testis Barrier Integrity in Testicular Carcinoma In Situ

Carcinoma in situ (CIS) is the noninvasive precursor of most human testicular germ cell tumors. In normal seminiferous epithelium, specialized tight junctions between Sertoli cells constitute the major component of the blood-testis barrier. Sertoli cells associated with CIS exhibit impaired maturati...

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Bibliographic Details
Main Authors: Cornelia Fink, Roswitha Weigel, Tanja Hembes, Heidrun Lauke-Wettwer, Sabine Kliesch, Martin Bergmann, Ralph H. Brehm
Format: Article
Language:English
Published: Elsevier 2006-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Blood-testis barrier
carcinoma in situ
ZO-1
ZO-2
lanthanum tracer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606801077

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http://www.sciencedirect.com/science/article/pii/S1476558606801077

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