Regulation of the HIF switch in human endothelial and cancer cells
Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metaboli...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933524000037 |
| _version_ | 1827207932337455104 |
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| author | Jakub Slawski Maciej Jaśkiewicz Anna Barton Sylwia Kozioł James F. Collawn Rafał Bartoszewski |
| author_facet | Jakub Slawski Maciej Jaśkiewicz Anna Barton Sylwia Kozioł James F. Collawn Rafał Bartoszewski |
| author_sort | Jakub Slawski |
| collection | DOAJ |
| description | Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metabolic change facilitates normal cell survival as well as cancer cell survival. The key feature in survival is the transition between acute hypoxia and chronic hypoxia, and this is regulated by the transition between HIF-1 expression and HIF-2/HIF-3 expression. This transition is observed in many human cancers and endothelial cells and referred to as the HIF Switch. Here we discuss the mechanisms involved in the HIF Switch in human endothelial and cancer cells which include mRNA and protein levels of the alpha chains of the HIFs. A major continuing effort in this field is directed towards determining the differences between normal and tumor cell utilization of this important pathway, and how this could lead to potential therapeutic approaches. |
| first_indexed | 2024-03-08T11:54:40Z |
| format | Article |
| id | doaj.art-a8db4514b4f84c12839ff955b08e8b07 |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2025-03-21T12:47:55Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-a8db4514b4f84c12839ff955b08e8b072024-06-27T04:38:11ZengElsevierEuropean Journal of Cell Biology0171-93352024-06-011032151386Regulation of the HIF switch in human endothelial and cancer cellsJakub Slawski0Maciej Jaśkiewicz1Anna Barton2Sylwia Kozioł3James F. Collawn4Rafał Bartoszewski5Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, PolandInternational Research Agenda 3P, Medicine Laboratory, Medical University of Gdansk, Gdansk, PolandDepartment of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, PolandDepartment of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, PolandDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USADepartment of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland; Correspondence to: Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, F. Joliot-Curie 14a Street, 50-383 Wroclaw, Poland.Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metabolic change facilitates normal cell survival as well as cancer cell survival. The key feature in survival is the transition between acute hypoxia and chronic hypoxia, and this is regulated by the transition between HIF-1 expression and HIF-2/HIF-3 expression. This transition is observed in many human cancers and endothelial cells and referred to as the HIF Switch. Here we discuss the mechanisms involved in the HIF Switch in human endothelial and cancer cells which include mRNA and protein levels of the alpha chains of the HIFs. A major continuing effort in this field is directed towards determining the differences between normal and tumor cell utilization of this important pathway, and how this could lead to potential therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S0171933524000037HypoxiaHuman endothelial cellsHIF1AEPAS1HIF3AHIF-1α |
| spellingShingle | Jakub Slawski Maciej Jaśkiewicz Anna Barton Sylwia Kozioł James F. Collawn Rafał Bartoszewski Regulation of the HIF switch in human endothelial and cancer cells European Journal of Cell Biology Hypoxia Human endothelial cells HIF1A EPAS1 HIF3A HIF-1α |
| title | Regulation of the HIF switch in human endothelial and cancer cells |
| title_full | Regulation of the HIF switch in human endothelial and cancer cells |
| title_fullStr | Regulation of the HIF switch in human endothelial and cancer cells |
| title_full_unstemmed | Regulation of the HIF switch in human endothelial and cancer cells |
| title_short | Regulation of the HIF switch in human endothelial and cancer cells |
| title_sort | regulation of the hif switch in human endothelial and cancer cells |
| topic | Hypoxia Human endothelial cells HIF1A EPAS1 HIF3A HIF-1α |
| url | http://www.sciencedirect.com/science/article/pii/S0171933524000037 |
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