Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer

Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer

Abstract Background Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematological malignancies with several approved products, but not in solid tumors. Patients suffer from limited response and tumor relapse due to low efficacy of CAR-T cells in the complicated and i...

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Bibliographic Details
Main Authors: Jianbin Ye, Qiaoyuan Liu, Yunxuan He, Zhenkun Song, Bao Lin, Zhiwei Hu, Juanyuan Hu, Yunshan Ning, Cheguo Cai, Yan Li
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
CAR-T
Solid tumor
Gastric cancer
IL-15/IL-15Rα
GLIPR1
Combined therapy
Online Access:https://doi.org/10.1186/s12967-024-04982-6

Internet

https://doi.org/10.1186/s12967-024-04982-6

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