The Effects of Human Recombinant Il-1β on Rat Hepatic and Renal Cytochrome P450-Mediated Monooxygenase Activities

The effects of human recombinant IL-1β (BETALEUKIN) (6 × 10 4 – 6 × 10 6 U/Kg, intraperitoneally, single dose) on liver histology and cytochrome P450 (CYP450s)-mediated hepatic and renal monooxygenase activities were studied in adult male rats. rIL-1β (24 h after treatment) caused proinflammatory ch...

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Bibliographic Details
Main Authors: S.V. Sibiryak, A.S. Simbirtsev, A.T. Akhmatov, D.S. Sibiryak
Format: Article
Language:English
Published: SAGE Publishing 2004-05-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X0400200202