Disruption of endosomal trafficking with EGA alters TLR9 cytokine response in human plasmacytoid dendritic cells

Disruption of endosomal trafficking with EGA alters TLR9 cytokine response in human plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDCs) exhibit bifurcated cytokine responses to TLR9 agonists, an IRF7-mediated type 1 IFN response or a pro-inflammatory cytokine response via the activation of NF-κB. This bifurcated response has been hypothesized to result from either distinct signaling endosomes or e...

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Bibliographic Details
Main Authors: Matthew J. Wiest, Chao Gu, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, HyeMee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, SangKon Oh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
EGA
endosomal trafficking
nucleic acid
plasmacytoid dendritic cells
toll-like receptor 9
type 1 interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1144127/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1144127/full

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