Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

Objective: Fibroblast growth factor 21 (FGF21) is a peripherally-derived endocrine hormone that acts on the central nervous system (CNS) to regulate whole body energy homeostasis. Pharmacological administration of FGF21 promotes weight loss in obese animal models and human subjects with obesity. How...

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Bibliographic Details
Main Authors: Kristin E. Claflin, Andrew I. Sullivan, Meghan C. Naber, Kyle H. Flippo, Donald A. Morgan, Tate J. Neff, Sharon O. Jensen-Cody, Zhiyong Zhu, Leonid V. Zingman, Kamal Rahmouni, Matthew J. Potthoff
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Molecular Metabolism
Subjects:
Neurons
FGF21
Betaklotho
Glutamatergic
Leptin
Adipose
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001338

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http://www.sciencedirect.com/science/article/pii/S2212877822001338

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