A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological processes. Lysine-specific demethylase 1 (LSD1), a fir...

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Bibliographic Details
Main Authors: Guan-Jun Yang, Yan-Jun Liu, Li-Jian Ding, Fan Tao, Ming-Hui Zhu, Zhen-Yuan Shi, Juan-Ming Wen, Meng-Yao Niu, Xiang Li, Zhan-Song Xu, Wan-Jia Qin, Chen-Jie Fei, Jiong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
LSD1
histone demethylase
breast cancer
inhibitors
H3K4me1/2
H3K9me1/2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.989575/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.989575/full

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