Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution

Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution

Abstract Background High-grade serous carcinoma (HGSC) is the most frequent and lethal type of ovarian cancer. It has been proposed that tubal secretory cells are the origin of ovarian HGSC in women with familial BRCA1/2 mutations. However, the molecular changes underlying malignant transformation r...

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Bibliographic Details
Main Authors: Xuexin Yu, Wanrun Lin, Alexandra Spirtos, Yan Wang, Hao Chen, Jianfeng Ye, Jessica Parker, Ci Ci Liu, Yiying Wang, Gabriella Quinn, Feng Zhou, Setsuko K. Chambers, Cheryl Lewis, Jayanthi Lea, Bo Li, Wenxin Zheng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Medicine
Subjects:
High-grade serous carcinoma
Ovarian cancer
BRCA1 mutation
Fallopian tube
Single-cell RNA sequencing
T cell exhaustion
Online Access:https://doi.org/10.1186/s12916-022-02489-9

Internet

https://doi.org/10.1186/s12916-022-02489-9

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