Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease

Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease

Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation in ischemic muscle disease. Methods: Caspase acti...

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Bibliographic Details
Main Authors: Ricardo Ferrari, Bowen Xie, Edwyn Assaf, Kristin Morder, Melanie Scott, Hong Liao, Michael J. Calderon, Mark Ross, Patricia Loughran, Simon C. Watkins, Iraklis Pipinos, George Casale, Edith Tzeng, Ryan McEnaney, Ulka Sachdev
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
inflammasomes
caspase-5
myoblasts
peripheral arterial disease
Online Access:https://www.mdpi.com/2073-4409/11/7/1163

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https://www.mdpi.com/2073-4409/11/7/1163

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