Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding a...

Full description

Bibliographic Details
Main Authors: Chaoyun Pan, JiHoon Kang, Jung Seok Hwang, Jie Li, Austin C. Boese, Xu Wang, Likun Yang, Titus J. Boggon, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Lingtao Jin, Sumin Kang
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24845-8

Internet

https://doi.org/10.1038/s41467-021-24845-8

Similar Items